Mast Cell Activation Syndrome (MCAS): Symptoms
Have you ever experienced unexplained and seemingly random symptoms such as hives, abdominal bloating, joint pain, or anxiety? It's possible that you may be suffering from Mast Cell Activation Syndrome (MCAS), a condition that is not yet widely recognized by the medical community but is gaining more attention in recent years.
What is Mast Cell Activation Syndrome (MCAS)?
Mast cells are a type of white blood cell that play a crucial role in the immune system by releasing histamine and other inflammatory molecules in response to a threat such as a virus or bacteria. However, in MCAS, the mast cells are over-activated, leading to the release of excessive amounts of histamine and other inflammatory molecules even in response to non-threatening triggers such as stress, environmental toxins, certain foods, or medications.
This chronic overstimulation of mast cells can lead to a wide range of symptoms affecting multiple systems in the body, including the skin, digestive system, musculoskeletal system, heart and lungs, endocrine system, and brain and nervous system.
What are the symptoms of Mast Cell Activation Syndrome (MCAS)?
The symptoms of MCAS can vary widely among individuals and can be triggered by a wide range of factors. Here are some of the most common symptoms:
Skin Manifestations:
Hives or welts
Itching
Hypersensitivity to insect bites
Skin flushing
Sun sensitivity
Digestive/Gastrointestinal Manifestations:
Abdominal bloating
Abdominal cramping
Constipation
Diarrhea
Heartburn
Peptic ulcer disease
Sensitivity to probiotics
Musculoskeletal Manifestations:
Joint pain
Muscle pain
Osteoporosis
Heart/Lung Manifestations:
Heart palpitation or sensation of fast beating, pounding heart
Temporary loss of consciousness caused by a fall in blood pressure
Abnormally rapid heartbeat
Wheezing
Ear/Eyes/Nose/Throat Manifestations:
Pink eye
Runny nose, especially after meals
Blocked sinuses
Endocrinological Manifestations:
Blood sugar instability
Fatigue
Sudden drop in blood pressure when you stand up from a seated or lying position
Brain/Neurological Manifestations:
Anxiety
Brain fog
Headaches
The severity of symptoms can vary widely depending on the individual and the triggering factors. Some people may experience mild symptoms that are easily managed, while others may experience severe and debilitating symptoms that affect their quality of life.
What are the common overlapping conditions associated with MCAS?
Mold Toxicitiy
Lyme Disease
MTHFR Gene Mutations
Ehlers-Danlos Syndrome
Neuroinflammatory Conditions
EMF Sensitivity
POTS
Cancer
Mast Cell Activation Syndrome (MCAS) is a complex and often overlooked medical condition that can significantly impact a person's quality of life. The symptoms of MCAS can be vague and overlap with other conditions, making diagnosis challenging.
References
https://ndnr.com/dermatology/mast-cell-activation-skin-is-just-scratching-the-surface/
https://www.aaaai.org (American Academy of Allergy, Asthma & Immunology
http://www.jillcarnahan.com/downloads/MCASReview.pdf